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KMID : 0603820170230010039
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Journal of Experimental & Biomedical Science
2017 Volume.23 No. 1 p.39 ~ p.43
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Hypothermia Regulates Insulin-like Growth Factor 1 Gene Expression in PC12 Cells
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Yoo Bo-Kyung
Kwon Ki-sang
Lee Eun-Ryeong
Kim Seung-Whan
Yu Kweon
Kwon O-Yu
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Abstract
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In this study, we evaluated the effects of various hypothermic conditions (32oC), including lithium chloride treatment, on insulin-like growth factor 1 (IGF-1) gene expression in PC12 cells. The results show that short-term hypothermic treatment (<1 day) resulted in relatively higher IGF-1 gene expression than did longer-term treatment (>1 day). Repeated switching between normal temperature and hypothermia every 2 h increased IGF-1 gene expression approximately 3-4-fold. These findings indicate that hypothermia dynamically regulates IGF-1 gene expression. This study could be helpful for the development of treatment and diagnostic strategies for ischemia.
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KEYWORD
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Hypothermia , Insulin-like growth factor 1 (IGF-1) , PC12 cells
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